Sydney FC only need a draw to finish second in the A-League, while Melbourne Victory look set to seal the Premier s Plate.
Graham Arnold s Sky Blues sit behind Victory, who are three points clear at the top, ahead of a trip to Wellington.
The Phoenix are a point behind Sydney, who will seal a top-two spot and a home semi-final should they avoid defeat.
Arnold s side are unbeaten in 13 away games this campaign, and they have won back-to-back games ahead of their trip to Westpac Stadium.
Sydney could still finish top, but they will need a win and goal difference turnaround of seven.
That is unlikely, given Victory host the eighth-placed Central Coast Mariners at AAMI Park on Sunday.
Austria captain Marc Janko is on track to win the golden boot, having scored 16 goals for Sydney – three more than Phoenix attacker Nathan Burns.
Wellington have been in scratchy form, with Ernie Merrick s side coming from behind to edge the Mariners 3-2 last time out.
Perth Glory, who visit the second-bottom Western Sydney Wanderers on Saturday, currently sit third but will be sent down to seventh for salary cap breaches.
Adelaide United are still eyeing third spot ahead of a meeting with Melbourne City at Coopers Stadium on Saturday.
If Josep Gombau s men win and the Phoenix lose, the Reds will jump into third and host the Brisbane Roar in the first week of the finals.
The Roar, fresh from a 1-0 win at Beijing Guoan in the AFC Champions League in mid-week, host the bottom-placed Newcastle Jets on Friday.
Victory complete the round when they host the Mariners, and Kevin Muscat s men are set to win their first piece of silverware since 2009.